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Direct One‐Pot Synthesis of Naphthoxindoles from 4‐Bromooxindoles by Suzuki–Miyaura Coupling and Aldol Condensation Reactions
Author(s) -
Park KyeongYong,
Kim Bum Tae,
Heo JungNyoung
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301242
Subject(s) - chemistry , aldol reaction , aldol condensation , cascade , coupling reaction , condensation , combinatorial chemistry , microwave irradiation , scope (computer science) , coupling (piping) , one pot synthesis , catalysis , organic chemistry , condensation reaction , mechanical engineering , physics , chromatography , engineering , thermodynamics , computer science , programming language
An efficient one‐pot synthesis of naphthoxindoles by using 4‐bromoindolin‐2‐ones and 2‐formylphenylboronic acids has been developed. The coupling reaction proceeds in good to excellent yields under microwave irradiation through a Suzuki–Miyaura coupling and an aldol condensation cascade reaction. In addition, this protocol permits the facile construction of naphthoxindoles through an expanded scope of substrates.