Titanium Isopropoxide Promoted Tandem Self‐Cross and Ring‐Closing Metathesis Approach for the Synthesis of Macrotetralides | Zendy

Muthusamy Sengodagounder | Zendy; Azhagan Datshanamoorthy | Zendy

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Titanium Isopropoxide Promoted Tandem Self‐Cross and Ring‐Closing Metathesis Approach for the Synthesis of Macrotetralides

Author(s) -

Muthusamy Sengodagounder,

Azhagan Datshanamoorthy

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201301239

Subject(s) - chemistry , ring closing metathesis , tandem , metathesis , catalysis , lewis acids and bases , salt metathesis reaction , titanium , selectivity , combinatorial chemistry , ring (chemistry) , organic chemistry , polymerization , materials science , composite material , polymer

A new approach is demonstrated for the synthesis of macrotetralides through an olefin metathesis reaction using Grubbs' second‐generation catalyst with titanium isopropoxide as a cocatalyst. This study demonstrates a tandem self‐cross and ring‐closing metathesis approach to form macrocyclic ring systems with excellent ( E ) selectivity. The reaction was optimized with regard to functional group, catalyst, solvent, Lewis acid, concentration, and temperature.

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