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Driving the Morita–Baylis–Hillman Reaction to a Multicomponent Organic Transformation
Author(s) -
Guillouzic AnneFrançoise,
Montel Sonia,
Laborde Coralie,
Volle JeanNoël,
Pirat JeanLuc,
Virieux David
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301226
Subject(s) - chemistry , reagent , aldehyde , phosphine , lewis acids and bases , baylis–hillman reaction , olefin fiber , transformation (genetics) , organic chemistry , organic synthesis , organocatalysis , michael reaction , base (topology) , organic molecules , combinatorial chemistry , molecule , catalysis , enantioselective synthesis , biochemistry , gene , mathematical analysis , mathematics
Abstract The combination of a trivalent phosphorus reagent with an aldehyde and a Michael olefin in the presence of water led to the formation of functionalized phosphine oxides. This approach turned the Lewis base organocatalyzed Morita–Baylis–Hillman reaction into a multicomponent organic transformation to provide rapid access to polyfunctionalized molecules.