Rhodium‐Catalyzed Intramolecular Difluoromethylenative Dearomatization of Phenols | Zendy

Li Yajun | Zendy; Zhang Lisi | Zendy; Zhang Li | Zendy; Wu Yongming | Zendy; Gong Yuefa | Zendy

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Rhodium‐Catalyzed Intramolecular Difluoromethylenative Dearomatization of Phenols

Author(s) -

Li Yajun,

Zhang Lisi,

Zhang Li,

Wu Yongming,

Gong Yuefa

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201301225

Subject(s) - chemistry , intramolecular force , rhodium , yield (engineering) , phenols , catalysis , quaternary carbon , organic chemistry , combinatorial chemistry , enantioselective synthesis , materials science , metallurgy

Rhodium‐catalyzed intramolecular difluoromethylenative dearomatization of phenols to yield azaspirocyclohexadienones containing all‐carbon quaternary centers in good to excellent yields was developed. A variety of functional groups proved compatible with the transformation. This method could also be used for difluoromethylenative dearomatization of indoles. Preliminary mechanism studies suggest that a pure radical mechanism is not involved in this reaction.

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