Premium
Rhodium‐Catalyzed Intramolecular Difluoromethylenative Dearomatization of Phenols
Author(s) -
Li Yajun,
Zhang Lisi,
Zhang Li,
Wu Yongming,
Gong Yuefa
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301225
Subject(s) - chemistry , intramolecular force , rhodium , yield (engineering) , phenols , catalysis , quaternary carbon , organic chemistry , combinatorial chemistry , enantioselective synthesis , materials science , metallurgy
Rhodium‐catalyzed intramolecular difluoromethylenative dearomatization of phenols to yield azaspirocyclohexadienones containing all‐carbon quaternary centers in good to excellent yields was developed. A variety of functional groups proved compatible with the transformation. This method could also be used for difluoromethylenative dearomatization of indoles. Preliminary mechanism studies suggest that a pure radical mechanism is not involved in this reaction.