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Applications of 2‐ C ‐Formyl‐Glycals in Organic Synthesis
Author(s) -
Ramesh Namakkal G.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301176
Subject(s) - chemistry , formylation , supramolecular chemistry , carbohydrate chemistry , organic chemistry , combinatorial chemistry , catalysis , molecule
The chemistry of 2‐ C ‐formyl‐glycals has witnessed tremendous growth over the last two decades. Functionalized compounds derived from 2‐ C ‐formyl‐glycals have found applications in organic synthesis, carbohydrate chemistry, medicinal chemistry, supramolecular chemistry, and materials chemistry. These advancements can be mainly attributed to the availability of a very simple and general procedure for the direct formylation of glycals by using the Vilsmeier–Haack reaction. The highly conjugated α,β‐unsaturated carbonyl functional group present in 2‐ C ‐formyl‐glycals provides opportunities for synthetic elaboration, which can lead to a variety of natural and unnatural compounds for varied applications. This review summarizes the recent developments in the synthesis and applications of these versatile chiral intermediates.