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Synthesis of (+)‐ O ‐Methylthalibrine by Employing a Stereocontrolled Bischler–Napieralski Reaction and an Electrochemically Generated Diaryl Ether
Author(s) -
Kawabata Yuki,
Naito Yu,
Saitoh Tsuyoshi,
Kawa Kohei,
Fuchigami Toshio,
Nishiyama Shigeru
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301128
Subject(s) - chemistry , halogenation , stereoselectivity , electrochemistry , ether , organic chemistry , redox , combinatorial chemistry , medicinal chemistry , catalysis , electrode
An efficient electrochemical four‐step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)‐ O ‐methylthalibrine was achieved by employing this strategy along with a stereoselective Bischler–Napieralski reaction.