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The Shortest (Four‐Step) Total Synthesis of the Eight‐Membered Cyclic Ether ( rac )‐ and (–)‐ cis ‐Lauthisan
Author(s) -
HernándezTorres Gloria,
Mateo Julio,
Urbano Antonio,
Carreño M. Carmen
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301042
Subject(s) - chemistry , stereoselectivity , sequence (biology) , ether , stereochemistry , total synthesis , organic chemistry , biochemistry , catalysis
Access to the eight‐membered cyclic ether ( rac )‐ and (–)‐ cis ‐lauthisan was achieved in two complementary ways in only four steps for the longest linear sequence by starting from commercially available materials. The sequence features a cis ‐stereoselective reductive cyclization as the key step.
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