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An (Aminopyrimidinato)titanium Catalyst for the Hydroamination of Alkynes and Alkenes
Author(s) -
Brahms Christian,
Tholen Patrik,
Saak Wolfgang,
Doye Sven
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301004
Subject(s) - hydroamination , chemistry , markovnikov's rule , catalysis , titanium , intermolecular force , organic chemistry , pyrimidine , combinatorial chemistry , regioselectivity , stereochemistry , molecule
A new (aminopyrimidinato)titanium complex has been synthesised from inexpensive and easily accessible 2‐( tert ‐butylamino)pyrimidine and [Ti(NMe 2 ) 4 ] and used as a catalyst for the intermolecular hydroamination of alkynes as well as the cyclization of aminoalkenes. The hydroamination reactions of 1‐phenylpropyne and terminal arylalkynes deliver the corresponding anti‐Markovnikov addition products with excellent yields and regioselectivities.