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Synthesis of gem ‐Difluoromethylenated Spiro‐γ‐butyrolactones by Employing PhSCF 2 Si(CH 3 ) 3 as a gem ‐Difluoromethylenating Agent
Author(s) -
Chatupheeraphat Adisak,
Soorukram Darunee,
Kuhakarn Chutima,
Tuchinda Patoomratana,
Reutrakul Vichai,
Pakawatchai Chaveng,
Saithong Saowanit,
Pohmakotr Manat
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300998
Subject(s) - chemistry , block (permutation group theory) , medicinal chemistry , stereochemistry , combinatorics , mathematics
PhSCF 2 TMS was utilized as a useful gem ‐difluoromethylene building block for the synthesis of gem ‐difluoromethylenated spiro‐γ‐butyrolactones. The radical cyclization of γ‐alkenyl‐γ‐ gem ‐difluoro(phenylsulfanyl)methyl‐γ‐butyrolactones provided gem ‐difluoromethylenated spiro‐γ‐butyrolactones.