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Synthesis of Tetrasubstituted α‐Aminophosphonic Acid Derivatives from Trisubstituted α‐Aminophosphonates
Author(s) -
Vicario Javier,
Ortiz Pablo,
Palacios Francisco
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300950
Subject(s) - chemistry , phosphonate , reagent , nucleophile , tartaric acid , organic chemistry , combinatorial chemistry , enantioselective synthesis , catalysis , citric acid
An efficient method for the preparation of quaternary α‐aminophosphonic acid derivatives is reported. The nucleophilic addition of organometallic reagents to α‐ketiminophosphonates allows the preparation of quaternary α‐aminophosphonates. The diastereoselective synthesis of a quaternary α‐aminophosphonate using a chiral tartaric‐acid‐derived phosphonate is also described.