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Photoactivable Nonsymmetrical Bifunctional Linkers for Protein Immobilization on Attenuated Total Reflectance FTIR Optical Devices
Author(s) -
Hammaecher Catherine,
Joris Bernard,
Goormaghtigh Erik,
MarchandBrynaert Jacqueline
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300939
Subject(s) - bifunctional , attenuated total reflection , chemistry , fourier transform infrared spectroscopy , maleimide , linker , infrared spectroscopy , polymer chemistry , organic chemistry , chemical engineering , catalysis , computer science , engineering , operating system
Abstract The photosensitive 4‐azido‐2,3,5,6‐tetrafluoro‐1‐benzoyl core has been connected to maleimide‐, chloroacetyloxy‐, or succinimidyl carbonate motifs through various spacers to furnish a series of bifunctional linkers. One linker ( 7a ) has been used for the construction of a biosensor for β‐lactam antibiotic detection by attenuated total reflectance FTIR (ATR‐FTIR) spectroscopy.