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Catalytic Synthesis of Functional Silicon‐Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon‐Centered Diols
Author(s) -
Lu Xing,
Li Li,
Yang Wei,
Jiang Kezhi,
Yang KeFang,
Zheng ZhanJiang,
Xu LiWen
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300932
Subject(s) - desymmetrization , candida antarctica , silanes , organosilicon , stereocenter , chemistry , lipase , silicon , catalysis , organic chemistry , stereochemistry , enantioselective synthesis , silane , enzyme
A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL‐B) (up to 90:10 er ).