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An Approach to 2,4‐Substituted Pyrazolo[1,5‐ a ]pyridines and Pyrazolo[1,5‐ a ]azepines by Ring‐Closing Metathesis
Author(s) -
Fustero Santos,
Román Raquel,
Asensio Amparo,
Maestro Miguel A.,
Aceña José L.,
SimónFuentes Antonio
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300901
Subject(s) - azepine , chemistry , ring closing metathesis , peptidomimetic , metathesis , bicyclic molecule , stereochemistry , pyridine , ring (chemistry) , closing (real estate) , combinatorial chemistry , medicinal chemistry , organic chemistry , polymer , political science , law , peptide , biochemistry , polymerization
The ring‐closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5‐ a ]pyridine and pyrazolo[1,5‐ a ]azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second ( i +1) and third ( i +2) fragments having been substituted by bicyclic frameworks is described.