Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl  N ‐ tert ‐Butanesulfinyl Hemiaminals | Zendy

Grellepois Fabienne | Zendy; Ben Jamaa Abdelkhalek | Zendy; Gassama Abdoulaye | Zendy

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Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N ‐ tert ‐Butanesulfinyl Hemiaminals

Author(s) -

Grellepois Fabienne,

Ben Jamaa Abdelkhalek,

Gassama Abdoulaye

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300890

Subject(s) - chemistry , trifluoromethyl , reagent , aryl , alkyl , organic chemistry , organolithium compounds , enantioselective synthesis , trifluoromethylation , medicinal chemistry , catalysis , ion , deprotonation

The asymmetric synthesis of trifluoromethylated tertiary and secondary carbinamines (α,α‐dibranched and α‐branched amines) was achieved by reaction of alkyl, aryl and allyl organomagnesium or organolithium reagents to trifluoromethyl N ‐ tert ‐butanesulfinyl hemiaminals, bench‐stable analogs of the corresponding ketoimines.

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