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Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N ‐ tert ‐Butanesulfinyl Hemiaminals
Author(s) -
Grellepois Fabienne,
Ben Jamaa Abdelkhalek,
Gassama Abdoulaye
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300890
Subject(s) - chemistry , trifluoromethyl , reagent , aryl , alkyl , organic chemistry , organolithium compounds , enantioselective synthesis , trifluoromethylation , medicinal chemistry , catalysis , ion , deprotonation
The asymmetric synthesis of trifluoromethylated tertiary and secondary carbinamines (α,α‐dibranched and α‐branched amines) was achieved by reaction of alkyl, aryl and allyl organomagnesium or organolithium reagents to trifluoromethyl N ‐ tert ‐butanesulfinyl hemiaminals, bench‐stable analogs of the corresponding ketoimines.