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Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin‐6‐one β‐Carboline Series and Study of Phenotypic Properties on C. elegans
Author(s) -
CebriánTorrejón Gerardo,
Mackiewicz Nicolas,
VázquezManrique Rafael P.,
Fournet Alain,
Figadère Bruno,
Nicolas Julien,
Poupon Erwan
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300770
Subject(s) - chemistry , tryptamine , stereochemistry , chemical synthesis , combinatorial chemistry , biochemistry , in vitro
Based on the biosynthetic line of canthin‐6‐one alkaloids from their simple precursors such as tryptamine, the present work is focused on the study of alternative protocol of the Bischler‐Napieralski reaction and has led to a full coverage of the different biosynthetic intermediates. Nanoparticles were also prepared as mimics of biosynthetic assembly lines and some interesting biological results in term of chemical ecology are also reported.