Total Syntheses of Isomeric Spiroacetal Marine Natural Products Attenols A and B | Zendy

Kumar Vemula Praveen | Zendy; Kavitha Nerella | Zendy; Chandrasekhar Srivari | Zendy

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Total Syntheses of Isomeric Spiroacetal Marine Natural Products Attenols A and B

Author(s) -

Kumar Vemula Praveen,

Kavitha Nerella,

Chandrasekhar Srivari

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300703

Subject(s) - chemistry , total synthesis , regioselectivity , dihydroxylation , stereoselectivity , stereochemistry , sharpless asymmetric dihydroxylation , palladium , organic chemistry , enantioselective synthesis , catalysis

The convergent total synthesis of two marine natural products, attenols A and B is achieved with excellent stereocontrol. The synthetic route is based on an enantio‐ and regioselective Sharpless dihydroxylation, palladium(0)‐catalyzed reduction to form δ‐hydroxy‐1‐enoates, stereoselective m CPBA‐mediated epoxidation, and Julia–Kocienski olefination.

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