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Palladium‐Catalyzed Direct Acylation of Ketoximes and Aldoximes from the Alcohol Oxidation Level through C–H Bond Activation
Author(s) -
Sharma Satyasheel,
Kim Minyoung,
Park Jihye,
Kim Mirim,
Kwak Jong Hwan,
Jung Young Hoon,
Oh Joa Sub,
Lee Youngil,
Kim In Su
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300649
Subject(s) - chemistry , acylation , catalysis , palladium , alcohol , organic chemistry , oxidative phosphorylation , alcohol oxidation , medicinal chemistry , biochemistry
Abstract A highly efficient palladium‐catalyzed oxidative ortho ‐acylation of O ‐methyl ketoximes and O ‐methyl aldoximes with benzylic and aliphatic alcohols from the alcohol oxidation level is described. This protocol potentially provides new opportunities to use readily available alcohols as starting materials for catalytic reactions, and represents a catalytic alternative to transcend the barriers imposed by classical Friedel–Crafts acylation.