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Tether‐Free Immobilized Bifunctional Squaramide Organocatalysts for Batch and Flow Reactions
Author(s) -
Kardos György,
Soós Tibor
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300626
Subject(s) - bifunctional , squaramide , chemistry , michael reaction , organocatalysis , adduct , flow chemistry , continuous flow , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , biochemical engineering , engineering
This paper describes the preparation of highly efficient, easily accessible, and robust immobilized bifunctional organocatalysts. There was no need to employ any tether to secure high enantio‐ and diastereoselectivities in various Michael addition reactions. The synthetically useful Michael adducts were obtained within reasonable reaction times with the advantage of easy product isolation and the possibility of automation by using a flow chemistry apparatus.