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Lewis Acid Mediated Fragmentation of Tetrazoles towards Triazoles
Author(s) -
El Kaïm Laurent,
Grimaud Laurence,
Pravin Patil
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300620
Subject(s) - isocyanide , tetrazole , adduct , chemistry , azide , fragmentation (computing) , lewis acids and bases , copper , combinatorial chemistry , organic chemistry , polymer chemistry , catalysis , computer science , operating system
If Ugi–azide adducts generated from tert ‐butyl isocyanide, primary amines, and aromatic aldehydes are oxidized by copper(II) salts, the resulting imino tetrazoles may be easily converted into triazoles through Lewis acid catalyzed fragmentation of the tetrazole under microwave conditions.