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RADA‐16: A Tough Peptide – Strategies for Synthesis and Purification
Author(s) -
ParadísBas Marta,
TullaPuche Judit,
Zompra Aikaterini A.,
Albericio Fernando
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300612
Subject(s) - chemistry , peptide , combinatorial chemistry , fragment (logic) , nanotechnology , condensation , molecule , organic chemistry , biochemistry , computer science , programming language , materials science , physics , thermodynamics
The self‐assembling capacity of certain molecules can be exploited for a diverse range of biomedical applications. The ionic complementary peptide RADA‐16 is well‐known for its propensity to self‐assemble, which derives from its architectural arrangement. Herein, we describe rational synthetic strategies of synthesis of RADA‐16 based on fragment condensation, and its subsequent purification through optimized methods. Our methodology should prove suitable for the preparation of other peptides prone to self‐assembly.