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A Method for the Rapid and Simple Measurement of the Magnitude and Relative Sign of 1 H– 19 F Coupling Constants
Author(s) -
Espinosa Juan F.,
Broughton Howard
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300611
Subject(s) - chemistry , coupling constant , sign (mathematics) , coupling (piping) , proton , analytical chemistry (journal) , magnitude (astronomy) , constant (computer programming) , spectrum (functional analysis) , simple (philosophy) , atomic physics , physics , nuclear physics , quantum mechanics , mathematical analysis , mechanical engineering , mathematics , astronomy , engineering , philosophy , epistemology , chromatography , computer science , programming language
Abstract A novel methodology based on a carbon‐selective 1D HSQC experiment is proposed for the determination of 1 H– 19 F coupling constants. The method offers rapid access to 1 H– 19 F coupling constants that cannot be directly measured from the 1 H NMR spectrum due to the complexity and/or broadening of the proton signals or because the values are very small. As an additional benefit, the method also provides the relative sign of the 1 H– 19 F coupling constant.