Premium
Diarylated Ethanones from Mo(CO) 6 ‐Mediated and Microwave‐Assisted Palladium‐Catalysed Carbonylative Negishi Cross‐Couplings
Author(s) -
Motwani Hitesh V.,
Larhed Mats
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300610
Subject(s) - negishi coupling , carbonylation , chemistry , aryl , carbon monoxide , palladium , combinatorial chemistry , catalysis , organic chemistry , alkyl
Two protocols for palladium‐catalysed carbonylative Negishi cross‐couplings were developed for aryl iodides and aryl bromides. The two main breakthroughs were that molybdenum hexacarbonyl [Mo(CO) 6 ] could be used as a solid in situ source of CO, and that controlled microwave irraditaion could be used for heating. Consequently, the reactions were safe (in contrast to when CO gas was used) and fast (in comparison to when conventional heating was used). The carbonylative cross‐coupling reactions were carried out using commercially available benzylzinc bromide in closed vials (90–120 °C for 0.5–1 h) to give a set of diarylated ethanones, a common pharmacophore found in several pharmaceuticals, in moderate to high isolated yields (47–84 %). The mild three‐component carbonylation protocol presented here is operationally simple, safe, and rapid, and the formation of the carbonylative Negishi cross‐coupling product is favoured over the product of Negishi cross‐coupling.