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Palladium(II) Catalyzed Suzuki/Sonogashira Cross‐Coupling Reactions of Sulfonates: An Efficient Approach to C2‐Functionalized Pyrimidines and Pyridines
Author(s) -
Quan ZhengJun,
Jing FuQiang,
Zhang Zhang,
Da YuXia,
Wang XiCun
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300592
Subject(s) - sonogashira coupling , chemistry , palladium , catalysis , suzuki reaction , pyridine , combinatorial chemistry , coupling reaction , organic chemistry
Pyrimidin‐2‐yl sulfonates, as a reaction partner, can be easily prepared from inexpensive commercial materials and are efficiently cross‐coupled with arylboronic acids and terminal alkynes by using Pd(OAc) 2 ‐catalyzed Suzuki and Sonogashira reactions. A wide array of C2‐functionalized pyrimidines have been prepared in good to excellent yields. 2‐Arylpyridines and 2‐(oct‐1‐ynyl)pyridine were also synthesized.