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One‐Step Stereoselective Synthesis of Trisubstituted Monofluoroalkenes from 3,3,3‐Trifluoropropionates
Author(s) -
Lecea Mercedes,
Grassin Adrien,
FerreiroMederos Leticia,
Choppin Sabine,
Urbano Antonio,
Carreňo M. Carmen,
Colobert Françoise
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300551
Subject(s) - stereoselectivity , chemistry , reagent , condensation , grignard reagent , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , physics , thermodynamics
Stereoselective synthesis of ( E )‐monofluoroalkenes was achieved in one step by condensation of organolithium or Grignard reagents with 3,3,3‐trifluoropropionates. Highly functionalized monofluoroalkenes were obtained in good to excellent yields and stereoselectivities.