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Silver‐Catalyzed Highly Regioselective Phosphonation of Arenes Bearing Electron‐Withdrawing Groups
Author(s) -
Mao Xuerong,
Ma Xiao,
Zhang Shuwei,
Hu Hongwen,
Zhu Chengjian,
Cheng Yixiang
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300545
Subject(s) - regioselectivity , chemistry , nitrobenzene , catalysis , polar effect , substrate (aquarium) , medicinal chemistry , organic chemistry , oceanography , geology
Abstract A highly efficient, Ag I /K 2 S 2 O 8 ‐mediated regioselective phosphonation reaction has been developed by using electron‐deficient directing groups. These phosphonation reactions were performed with N , N ‐dialkylbenzamides, N , N ‐dialkylbenzenesulfonamides, and nitrobenzene. This method has a broad substrate scope and offers facile construction of C–P bonds.