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Copper‐Catalyzed Amidation of Acids Using Formamides as the Amine Source
Author(s) -
Xie YeXiang,
Song RenJie,
Yang XuHeng,
Xiang JianNan,
Li JinHeng
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300543
Subject(s) - formamides , chemistry , catalysis , organic chemistry , amine gas treating , acetamide , amino acid , alkyl , aryl , copper , octane , ligand (biochemistry) , biochemistry , receptor
Copper‐catalyzed amidation of acids with formamides or acetamide for the selective synthesis of amides with the aid of 1,4‐diazabicyclo[2.2.2]octane as the ligand and tert ‐butyl hydroperoxide as the oxidant is presented. This method is highly compatible with a wide range of acids, including alkyl acids, aryl acids, α,β‐unsaturated acids, and amino acids.