Highly Regioselective Addition of Organozinc Reagents to 2‐Oxo‐1,2‐dihydropyrimidine‐5‐carboxylates Activated by BF 3 ·OEt 2 : Synthesis of 2‐Oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylates | Zendy

Singh Kamaljit | Zendy; Chopra Rakesh | Zendy

Premium

Highly Regioselective Addition of Organozinc Reagents to 2‐Oxo‐1,2‐dihydropyrimidine‐5‐carboxylates Activated by BF 3 ·OEt 2 : Synthesis of 2‐Oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylates

Author(s) -

Singh Kamaljit,

Chopra Rakesh

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300539

Subject(s) - chemistry , regioselectivity , reagent , alkyl , carboxylate , medicinal chemistry , stereochemistry , antagonist , agonist , organic chemistry , catalysis , receptor , biochemistry

The incorporation of alkyl as well as phenyl groups at C‐4, a key position of 2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylates, responsible for antagonist/agonist switching of the calcium channel blocking activity of these compounds, has been achieved by the addition of organozinc reagents to the corresponding 2‐oxo‐1,2‐dihydropyrimidine‐5‐carboxylate derivatives catalysed by BF 3 OEt 2 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research