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Catalytic Asymmetric Allylic Alkylation of 3‐Arylated Piperidin‐2‐ones
Author(s) -
Michon Christophe,
Béthegnies Aurélien,
Capet Frédéric,
Roussel Pascal,
de Filippis Arnault,
GomezPardo Domingo,
Cossy Janine,
AgbossouNiedercorn Francine
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300510
Subject(s) - tsuji–trost reaction , alkylation , enantioselective synthesis , chemistry , catalysis , aryl , allylic rearrangement , optically active , combinatorial chemistry , palladium , quaternary carbon , organic chemistry , alkyl
The preparation of optically active lactams from 3‐aryl‐2‐piperidinone is reported. The quaternary carbon stereocentres were formed using palladium‐catalysed asymmetric allylic alkylation reactions. The resulting enantioenriched compounds are useful intermediates for the synthesis and development of neurokinin antagonists.