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Roadmap towards N‐Heterocyclic [2.2]Paracyclophanes and Their Application in Asymmetric Catalysis
Author(s) -
Busch Mark,
Cayir Merve,
Nieger Martin,
Thiel Werner R.,
Bräse Stefan
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300508
Subject(s) - chemistry , pyrazole , catalysis , conjugate , pyrimidine , ligand (biochemistry) , combinatorial chemistry , enantioselective synthesis , palladium , stereochemistry , organic chemistry , mathematical analysis , biochemistry , receptor , mathematics
A novel family of [2.2]paracyclophane derivatives is described. Different substituted pyrazole, triazole and pyrimidine moieties were introduced to the [2.2]paracyclophane scaffold and the products were characterized spectroscopically and by X‐ray structure analysis. These compounds are promising ligands for application in asymmetric catalysis. We show here that one of these ligands can catalyze asymmetric conjugate addition. Furthermore a palladium complex was synthesized by using a hydroxy‐pyrazolyl[2.2]paracyclophane ligand.