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An Efficient Organocatalysis: A One‐Pot Highly Enantioselective Synthesis of α‐Aminophosphonates
Author(s) -
Thorat Prashant B.,
Goswami Santosh V.,
Magar Rupali L.,
Patil Bhagwan R.,
Bhusare Sudhakar R.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300494
Subject(s) - chemistry , enantioselective synthesis , organocatalysis , enantiomer , reactivity (psychology) , organic chemistry , enantiomeric excess , optically active , combinatorial chemistry , catalysis , one pot synthesis , medicine , alternative medicine , pathology
This present method deals with an exceedingly rare aspect of α‐aminophosphonate synthesis. We studied an enantioseletive one‐pot synthetic method for the syntheses of optically active α‐aminophosphonates by employing an organocatalyst. Some new organocatalysts were synthesized and studied for their reactivity and enantioselectivity. The organocatalyst effectively catalyzed the reaction and provided the corresponding α‐aminophosphonates in high yields (71–90 %) with excellent enantiomeric excess values (73–92 %).