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Iron‐Mediated Decarboxylative Trifluoromethylation of α,β‐Unsaturated Carboxylic Acids with Trifluoromethanesulfinate
Author(s) -
Patra Tuhin,
Deb Arghya,
Manna Srimanta,
Sharma Upendra,
Maiti Debabrata
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300473
Subject(s) - trifluoromethylation , chemistry , inert gas , inert , carboxylic acid , organic chemistry , decarboxylation , atmosphere (unit) , catalysis , trifluoromethyl , alkyl , physics , thermodynamics
A sustainable FeCl 3 ‐mediated method has been developed for the decarboxylative trifluoromethylation of α,β‐unsaturated carboxylic acids by using NaSO 2 CF 3 as an economic and stable CF 3 source. The reaction proceeds under mild condition and tolerates various functional groups. Advantageously, this method does not require an inert atmosphere and proceeds well in air at ambient temperature.