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The Disubstitution of Acetals to Prepare δ,δ‐Bis(aryl) β‐Keto Esters
Author(s) -
Priebbenow Daniel L.,
Zou LiangHua,
Becker Peter,
Bolm Carsten
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300446
Subject(s) - chemistry , nucleophile , lewis acids and bases , silylation , aryl , silyl enol ether , organic chemistry , enol , catalysis , ether , alkyl
An efficient catalytic protocol for the synthesis of δ,δ‐bis(aryl)‐substituted β‐keto esters has been developed. This method involves the Lewis acid catalysed disubstitution reaction of ester‐substituted silyl enol ether acetals with a series of aromatic nucleophiles to afford valuable functionalized β‐keto esters with several sites available for further derivatisation.