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A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay
Author(s) -
Chamakuri Srinivas,
Guduru Shiva Krishna Reddy,
Pamu Sreedhar,
Chandrasekar Gayathri,
Kitambi Satish Srinivas,
Arya Prabhat
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300409
Subject(s) - zebrafish , chemistry , moiety , modular design , image stitching , chemical space , scaffold , combinatorial chemistry , computational biology , nanotechnology , drug discovery , stereochemistry , biochemistry , artificial intelligence , biomedical engineering , computer science , biology , engineering , materials science , gene , operating system
A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent “stitching technology”. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.