A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay | Zendy

Chamakuri Srinivas | Zendy; Guduru Shiva Krishna Reddy | Zendy; Pamu Sreedhar | Zendy; Chandrasekar Gayathri | Zendy; Kitambi Satish Srinivas | Zendy; Arya Prabhat | Zendy

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A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay

Author(s) -

Chamakuri Srinivas,

Guduru Shiva Krishna Reddy,

Pamu Sreedhar,

Chandrasekar Gayathri,

Kitambi Satish Srinivas,

Arya Prabhat

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300409

Subject(s) - zebrafish , chemistry , moiety , modular design , image stitching , chemical space , scaffold , combinatorial chemistry , computational biology , nanotechnology , drug discovery , stereochemistry , biochemistry , artificial intelligence , biomedical engineering , computer science , biology , engineering , materials science , gene , operating system

A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent “stitching technology”. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.

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