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Copper‐Catalyzed Synthesis of Nitriles by Aerobic Oxidative Reaction of Alcohols and Ammonium Formate
Author(s) -
Yadav Dilip Kumar T.,
Bhanage Bhalchandra M.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300361
Subject(s) - chemistry , ammonium formate , catalysis , formate , copper , organic chemistry , ammonium , oxidative phosphorylation , solvent , nitrogen , inorganic chemistry , acetonitrile , biochemistry
An efficient methodology has been developed for the synthesis of nitriles through an aerobic oxidative reaction of alcohols and ammonium formate with copper as a homogeneous catalyst under a normal air atmosphere and solvent‐free conditions. This protocol uses the air as a green oxidant and ammonium formate as the nitrogen source. A wide range of substrates were well tolerated in the reaction that gave water as a byproduct.