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Theophyllinylpyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3‐Diazepines and Imidazopurines
Author(s) -
Lebedyeva Iryna O.,
Povstyanoy V'yacheslav M.,
Ryabitskii Aleksey B.,
Panasyuk Oleksandr,
Ivahnenko Evgen,
Lozova Vera P.,
Markevich Igor,
Allakhverdova Svitlana,
Povstyanoy Mykhaylo V.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300360
Subject(s) - chemistry , diazepine , pyrimidine , intramolecular force , reactive intermediate , purine metabolism , combinatorial chemistry , theophylline , stereochemistry , organic chemistry , ring (chemistry) , catalysis , enzyme , endocrinology , medicine
Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis‐heterocyclic systems resulted in the formation of the corresponding diazepine moieties. In addition, modification of the reaction conditions led to the formation of imidazo[2,1‐ f ]purines.