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Scalable Synthesis of Enantiomerically Pure cis ‐1,2‐Cyclohexanediamine Derivatives and Conformationally Rigid 7‐Azabicyclo[2.2.1]heptan‐2‐amines
Author(s) -
Pandey Ganesh,
Dey Debasis,
Fernandes Rushil
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300253
Subject(s) - chemistry , carboxylate , stereochemistry , organic chemistry , medicinal chemistry , combinatorial chemistry
A scalable approach to the syntheses of enantiomerically pure cis ‐1,2‐cyclohexanediamines as well as exo ‐ and endo ‐7‐azabicyclo[2.2.1]heptan‐2‐amines is reported that utilizes meso ‐ tert ‐butyl 2,3‐bis(phenylsulfonyl)‐7‐azabicyclo[2.2.1]hept‐2‐ene‐7‐carboxylate as a starting material.