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Efficient Consecutive Four‐Component Synthesis of 5‐Acylpyrid‐2‐ones Initiated by Copper‐Free Alkynylation
Author(s) -
Nordmann Jan,
Breuer Natascha,
Müller Thomas J. J.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300235
Subject(s) - chemistry , alkynylation , stoichiometry , catalysis , component (thermodynamics) , combinatorial chemistry , copper , scope (computer science) , reaction conditions , sequence (biology) , organic chemistry , biochemistry , physics , computer science , thermodynamics , programming language
Abstract A one‐pot, consecutive, four‐component synthesis of 5‐acylpyrid‐2‐ones initiated by Pd/cataCXium ® ABn catalysis proceeds under mild reaction conditions and in good yields, with a broad scope of three points of diversity. This sequence is superior to the initially proposed Pd/Cu‐catalyzed version because all four components can be employed in close to stoichiometric amounts.