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Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity‐Oriented Synthesis
Author(s) -
Serba Christelle,
Winssinger Nicolas
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300201
Subject(s) - natural product , chemistry , lead (geology) , natural (archaeology) , biochemical engineering , diversity (politics) , cascade , divergent synthesis , product (mathematics) , combinatorial chemistry , organic chemistry , engineering , sociology , catalysis , biology , paleontology , anthropology , geometry , mathematics , chromatography
This microreview discusses recent efforts in chemical synthesis to design divergent pathways either to access diverse natural products from a common intermediate or to produce diverse libraries of compounds reminiscent of natural products. These efforts are generally based on the development and use of powerful complexity‐generating reactions and cascade reactions. A panel of eighteen examples is used to illustrate different strategies.