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Synthesis of Nitroalkenes Involving a Cooperative Catalytic Action of Iron(III) and Piperidine: A One‐Pot Synthetic Strategy to 3‐Alkylindoles, 2 H ‐Chromenes and N ‐Arylpyrrole
Author(s) -
Jalal Swapnadeep,
Sarkar Soumen,
Bera Krishnendu,
Maiti Sukhendu,
Jana Umasish
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300172
Subject(s) - chemistry , piperidine , catalysis , nucleophile , electrophile , combinatorial chemistry , indole test , michael reaction , organic chemistry , reaction conditions , environmentally friendly , ecology , biology
An efficient and simple strategy has been developed to synthesize various substituted nitroalkenes involving a cooperative catalytic system of FeCl 3 and piperidine. This dual catalytic protocol simultaneously activates both electrophile and nucleophile and works under mild reaction conditions so that many sensitive functional groups were tolerated. Moreover, this cooperative catalytic reaction is also suitable for various one‐pot reactions involving nitroalkenes such as, 2 H ‐chromenes, N ‐arylpyrrole and Michael reaction with indole. Notably, this method is low‐cost, efficient and environmentally friendly.