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Extending the Scope of the Aza‐Fischer Synthesis of 4‐ and 6‐Azaindoles
Author(s) -
Thomae David,
Jeanty Matthieu,
Coste Jérome,
Guillaumet Gérald,
Suzenet Franck
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300167
Subject(s) - chemistry , microwave irradiation , scope (computer science) , cascade , indole test , combinatorial chemistry , cascade reaction , stereochemistry , organic chemistry , catalysis , chromatography , computer science , programming language
Fischer indole cyclization has recently been described as an efficient approach to the synthesis of azaindoles bearing electron‐donating groups. We now show that this cascade reaction can be very efficient for the formation of a wider range of 4‐ and 6‐azaindoles by using microwave irradiation.