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Ruthenium‐Catalyzed Transfer Hydrogenation of Nitriles: Reduction and Subsequent N ‐Monoalkylation to Secondary Amines
Author(s) -
Werkmeister Svenja,
Bornschein Christoph,
Junge Kathrin,
Beller Matthias
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300151
Subject(s) - chemistry , ruthenium , catalysis , transfer hydrogenation , domino , organic chemistry , chemical reduction , combinatorial chemistry , electrode , electrochemistry
The selective synthesis of amines continues to be of importance because of their application in the bulk and fine chemical industries. Herein, domino ruthenium‐catalyzed transfer hydrogenation of nitriles with subsequent N ‐monoalkylation by using alcohols is described. With this novel approach, various nitriles were reductively N ‐monoalkylated in excellent yields.