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Gold(I)‐Catalyzed Post‐Ugi Hydroarylation: An Approach to Pyrrolopyridines and Azepinoindoles
Author(s) -
Kumar Amit,
Vachhani Dipak D.,
Modha Sachin G.,
Sharma Sunil K.,
Parmar Virinder S.,
Van der Eycken Erik V.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300132
Subject(s) - chemistry , ugi reaction , nucleophile , catalysis , combinatorial chemistry , ring (chemistry) , component (thermodynamics) , closure (psychology) , reaction conditions , organic chemistry , isocyanide , physics , economics , market economy , thermodynamics
A diversity‐oriented approach comprising a Ugi four‐component reaction and gold(I)‐catalyzed hydroarylation under very mild reaction conditions has been elaborated. This gives direct access to the synthesis of biologically important heterocycles such as pyrrolopyridines, pyridoindoles, and azepinoindoles in very good yields. The influence of the nucleophilicity of the heterocycle and the mode of ring closure are discussed.