Premium
Synthesis and Characterization of β‐Trifluoromethyl‐Substituted Pyrrolidines
Author(s) -
Yarmolchuk Vladimir S.,
Shishkin Oleg V.,
Starova Viktoriia S.,
Zaporozhets Olga A.,
Kravchuk Olga,
Zozulya Sergey,
Komarov Igor V.,
Mykhailiuk Pavel K.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300121
Subject(s) - trifluoromethyl , chemistry , pyrrolidine , cycloaddition , organic chemistry , characterization (materials science) , combinatorial chemistry , nanotechnology , catalysis , materials science , alkyl
A practical synthetic approach to the construction of a library of three isomeric/homologous β‐trifluoromethyl‐substituted pyrrolidines is disclosed. All products were prepared in multigram quantities from a common precursor. The key synthetic step was a [3+2] cycloaddition reaction. The influence of the trifluoromethyl group on the physicochemical characteristics of the pyrrolidine fragment was studied.