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(β‐ D ‐Ribofuranosyl)formamidine in the Design and Synthesis of 2‐(β‐ D ‐Ribofuranosyl)pyrimidines, Including R F ‐Containing Derivatives
Author(s) -
Iaroshenko Viktor O.,
Dudkin Sergii,
Sosnovskikh Vyacheslav Ya.,
Villinger Alexander,
Langer Peter
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300107
Subject(s) - chemistry , alkoxy group , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
A wide range of novel 2‐(β‐ D ‐ribofuranosyl)pyrimidines, including R F ‐containing derivatives, have been synthesized by the reaction of (β‐ D ‐ribofuranosyl)formamidine with various dielectrophilic substrates such as 3‐alkoxy‐ and 3‐chloro‐1‐(polyfluoroalkyl)propen‐1‐ones, 3‐nitro‐ and 3‐(phenylethynyl)chromones and heteroaryl acetylenic ketones.