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Total Syntheses of Eudistomins Y 1 –Y 7 by an Efficient One‐Pot Process of Tandem Benzylic Oxidation and Aromatization of 1‐Benzyl‐3,4‐dihydro‐β‐Carbolines
Author(s) -
Trieu Tien Ha,
Dong Jing,
Zhang Qiang,
Zheng Bo,
Meng TianZhuo,
Lu Xia,
Shi XiaoXin
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300080
Subject(s) - aromatization , chemistry , tandem , total synthesis , oxidation process , medicinal chemistry , organic chemistry , stereochemistry , catalysis , chemical engineering , materials science , engineering , composite material
The first total synthesis of eudistomin Y 7 ( 7 ) and total syntheses of eudistomins Y 1 –Y 6 ( 1 – 6 ) are described. An efficient room‐temperature conversion of 1‐benzyl‐3,4‐dihydro‐β‐carbolines ( 11 ) into 1‐benzoyl‐β‐carbolines ( 14 ) by a one‐pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail.