Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α‐Helix‐Mediated p53– h DM2 Protein–Protein Interaction | Zendy

Prabhakaran Panchami | Zendy; Barnard Anna | Zendy; Murphy Natasha S. | Zendy; Kilner Colin A. | Zendy; Edwards Thomas A. | Zendy; Wilson Andrew J. | Zendy

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Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α‐Helix‐Mediated p53– h DM2 Protein–Protein Interaction

Author(s) -

Prabhakaran Panchami,

Barnard Anna,

Murphy Natasha S.,

Kilner Colin A.,

Edwards Thomas A.,

Wilson Andrew J.

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300069

Subject(s) - chemistry , substituent , monomer , oligomer , alkyl , alkylation , solubility , helix (gastropod) , stereochemistry , combinatorial chemistry , organic chemistry , polymer , ecology , snail , biology , catalysis

This paper describes the design, synthesis and structural analysis of a 3‐ O ‐alkylated aromatic oligoamide that incorporates an additional hydrophilic 6‐ O ‐alkyl substituent in the central monomer. This oligomer exhibits low μ M inhibitory potency against the p53– h DM2 interaction compared with its unfunctionalised counterpart and significantly improved solubility.

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