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Self‐Assembling Multivalency – Supramolecular Polymers Assembled from Monovalent Mannose‐Labelled Discotic Molecules
Author(s) -
PetkauMilroy Katja,
Brunsveld Luc
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300057
Subject(s) - supramolecular chemistry , chemistry , supramolecular polymers , self assembly , ligand (biochemistry) , monomer , polymer , combinatorial chemistry , supramolecular assembly , molecule , lectin , nanotechnology , organic chemistry , materials science , biochemistry , receptor
Supramolecular synthesis, the “bottom‐up” construction of higher‐order structures from monomeric building blocks, represents a flexible approach for the generation of multivalent materials. Here, monovalent building blocks decorated with a single bioactive ligand were synthesized. In water, these supramolecular elements self‐assemble into columnar polymers that display multiple ligands. The supramolecular effect on the binding affinity was evaluated by using an enzyme‐linked lectin assay, and the self‐assembled architecture exhibited a stronger inhibitory power than that of the monovalent bioactive ligand. This so‐called self‐assembling multivalency enables the rapid and flexible generation of multivalent polymers from monovalent building blocks.