A Convenient Route to 1‐Alkyl‐5‐trifluoromethyl‐1,2,3‐triazole‐4‐carboxylic Acids Employing a Diazo Transfer Reaction | Zendy

Iminov Rustam T. | Zendy; Mashkov Alexander V. | Zendy; Chalyk Bohdan A. | Zendy; Mykhailiuk Pavel K. | Zendy; Tverdokhlebov Anton V. | Zendy; Tolmachev Andrey A. | Zendy; Volovenko Yulian M. | Zendy; Shishkin Oleg V. | Zendy; Shishkina Svetlana V. | Zendy

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A Convenient Route to 1‐Alkyl‐5‐trifluoromethyl‐1,2,3‐triazole‐4‐carboxylic Acids Employing a Diazo Transfer Reaction

Author(s) -

Iminov Rustam T.,

Mashkov Alexander V.,

Chalyk Bohdan A.,

Mykhailiuk Pavel K.,

Tverdokhlebov Anton V.,

Tolmachev Andrey A.,

Volovenko Yulian M.,

Shishkin Oleg V.,

Shishkina Svetlana V.

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201300030

Subject(s) - chemistry , trifluoromethyl , diazo , alkyl , azide , hydrolysis , 1,2,3 triazole , organic chemistry , triazole , medicinal chemistry

The reaction of ethyl 3‐(alkylamino)‐4,4,4‐trifluoro‐but‐2‐enoates with mesyl azide in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) gave ethyl 1‐alkyl‐5‐trifluoromethyl‐1,2,3‐triazole‐4‐carboxylates in good yields. Further hydrolysis of the ester group afforded the title compounds on a multigram scale.

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