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Synthesis of 5‐Organotellanyl‐1 H ‐1,2,3‐triazoles: Functionalization of the 5‐Position Scaffold by the Sonogashira Cross‐Coupling Reaction
Author(s) -
Stefani Hélio A.,
Vasconcelos Stanley N. S.,
Manarin Flávia,
Leal Daiana M.,
Souza Frederico B.,
Madureira Lucas Sousa,
ZukermanSchpector Julio,
Eberlin Marcos N.,
Godoi Marla N.,
de Souza Galaverna Renan
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201300009
Subject(s) - sonogashira coupling , chemistry , regioselectivity , cycloaddition , surface modification , combinatorial chemistry , coupling reaction , click chemistry , stereochemistry , organic chemistry , palladium , catalysis
An efficient synthesis of 5‐organotellanyl‐1 H ‐1,2,3‐triazole compounds was accomplished through [3+2] cycloaddition reaction of organic azides and (organotellanyl)alkynes. Additionally, 5‐organotellanyl‐1 H ‐1,2,3‐triazoles were readily functionalized at the 5‐position by using a Sonogashira cross‐coupling reaction, leading to highly functionalised triazoles. The regiochemistry of the products was assessed by two‐dimensional NMR spectroscopic experiments and X‐ray crystallography.