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Fused Arene Ring Construction Around Pyrrole To Form 4,7‐Disubstitued Indole (Eur. J. Org. Chem. 22/2012)
Author(s) -
Nojman Elżbieta,
LatosGrażyński Lechosław,
Szterenberg Ludmiła
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201290057
Subject(s) - chemistry , pyrrole , indole test , ring (chemistry) , trifluoroacetic acid , benzene , cover (algebra) , stoichiometry , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , mechanical engineering , engineering
The cover picture shows the original route for the synthesis of indoles. Treatment of the fundamental substrates, disubstituted 2‐butynes, with a stoichiometric amount of trifluoroacetic acid affords 4,7‐disubstituted indoles as the main products. The reported strategy involves attaching the benzene ring onto the existing pyrrole scaffold. Details are discussed in the article by L. Latos‐Grażyński et al. on p. 4115 ff.